UPDATE OCTOBER 2024
[Nova] rework will allow you to use Slowva and Speedva simultaneously and changes the strength threshold for maximum slow and speed to 150% strength. Her new passive will also cause kills on slowed enemies to have a 15% chance to drop health orbs which helps with energy economy via [Equilibrium], whereas kills on sped up enemies have a 15% chance to drop energy orbs. Killing 20 slowed enemies on average drops 3 health orbs which is equivalent to 165 energy.

The updated augments [Neutron Star] and [Molecular Fission] now give additional useful effects rather than previously used exclusively for health tanking.
1. [Molecular Fission]: [Molecular Fission] now allows Null Stars to apply Molecular Prime to enemies hit directly by a star, so Null Stars will automatically seek enemies out in approx 12-20m radius and apply molecular prime if not already primed (or alternatively seek multiple enemies at once if you press 1 with [Neutron Star] to release all particles). This means you effectively can apply Molecular Prime against nearby enemies WITHOUT recasting Molecular Prime nor needing to wait for the slow spread of the wave to touch targets, which is extremely useful for a more mobile playstyle.
2. [Neutron Star]: [Neutron Star] causes all remaining stars to seek enemies upon recasting 1, meaning you can prime multiple nearby enemies with Molecular Prime on demand. In addition [Neutron Star] applies forced HEAT status in an AOE which causes a brief stun animation which is significantly prolonged by the slow from Molecular Prime while also partially stripping some armor over time (up to 50% after 2s - which is effectively a 3.7x damage multiplier against armored enemies). If you subsume Nourish, you can actually apply viral to each [Neutron Star] AOE and rapidly and passively prime enemies all around you with both viral and heat. Note however the heat statuses are slightly detrimental to weapons that rely heavily on Heat status DPS since you will cause "reverse heat inherit" where heat procs from a DPS weapon inherit the lack of heat mods on [Neutron Star], if [Neutron Star] causes the initial heat proc on an enemy.

OTHER VARIANTS:
High Range Nourish variant (NEEDS SHARDS): https://overframe.gg/build/739390/
Silence Slow Nova variant: https://overframe.gg/build/738571/
Full EHP Tank Slowva: https://overframe.gg/build/230479/
Resonator Speedva: https://overframe.gg/build/215299/
Super Speedva with Rage: https://overframe.gg/build/455222/
Pillage ability DPS/nuke: https://overframe.gg/build/534481/
Nourish ability DPS/nuke: https://overframe.gg/build/442240/
Terrify Nuke Super Slowva: https://overframe.gg/build/442252/

PLAYSTYLE

1. Tap cast 4 (molecular prime) to slow enemies down by 75% or hold cast 4 (molecular prime) to speed enemies up by 75%.
2. Tap 1 to activate null stars, occasionally recast 1 to shoot all null stars to hit enemies with heat procs and molecular prime
3. Use 3 for quick map traversal and also as a shield gating tool while simultaneously escaping enemy fire
4. Use 2 for low level nuking

SURVIVABILITY

Shield Gating
In higher level steel path or endurance steel path (e.g. over level 500), we need to utilise a combination of shield gating and crowd control to survive. Shield gating is achieved via [Brief Respite] and Augur Mods to generate shields by casting abilities. Without [Catalyzing Shields] but with [Brief Respite] and about 3 augur mods (e.g 1 on frame and 2 on pistol), each cast of 2 gives about 0.9s gate, each cast of 3 gives about 1s gate and a cast of 4 gives 1.45s gate. With only [Brief Respite], casting 1 gives 0.5s gate, casting 3 gives 0.8s gate and casting 4 gives 0.9s gate. Adding [Catalyzing Shields] means every single ability cast gives enough shields for a 1.33s gate. Rolling Guard is very useful to provide additional i-frames as well as status cleanse. Crowd Control is easy due to Molecular Prime's slow combined with forced heat procs from [Neutron Star] which is automatically released as enemies get closer.

Tanking
Since Nullstars provides 90% damage reduction and now applies to both shields and health, keeping 1 active at all times (which is basically 100% with [Molecular Fission]) allows you to passively tank low levels (e.g. base SP up to level 500) quite easily. Swap [Rolling Guard] for [Adaptation] and add Arcane Blessing and [Guardian].

BUILD SPECIFICS

Duration
Duration affects the final expansion range of Molecular Prime as well as the number of null star particles. At approxiamtely 200% duration, Molecular Prime spreads 65m and Null Star has 24 particles. This means pressing 1 (with [Neutron Star]) can spread 24 stars to hit up to 24 enemies and apply Molecular Prime.

Efficiency
Neutral efficiency allows you to cast wormhole and molecular prime with relative frequency, although the [Molecular Fission] augment will allow you to passive apply molecular prime via null star particles. [Nova]'s passive also means you can generate tons of energy via health orbs and [Equilibrium]. This means you can run between 45% efficiency to 100% efficiency depending on preference. I prefer 100% efficiency if using wormhole alot as it is a very expensive ability or in endurance as you will be using alot of abilities for shield gating, and 45% efficiency for more casual missions where you don't need to cast alot. See this low efficiency higher range variant: https://overframe.gg/build/739390/

Range
Positive range increases the range of Wormhole, radius of Antimatter Drop and seek radius of Null Star and explosion radius of [Neutron Star]. You can adjust this between 145 to 235+ if you have the capacity.

Strength
150% strength is the threshold required for 75% slow and speed. Without shards you can use some combination of [Umbral Intensify] + [Power Drift]. WIth shards you can use [Augur Secrets] + two crimson shards. You can also use Precision Intensify if you prefer but then you don't boost the damage of 1 or 2 or the helminth you subsume (e.g. Nourish).

Aura
- Brief respite helps shield gating

Exilus
- Power drift to help hit thresholds
- Primed sure footed (best in slot but needs additional forma and login reward)
- Escape velocity or Prepration for speedrunning

Flexible Slots

• Rolling guard is optional but helps clear status effects and gives i-frames.
• [Catalyzing Shields] if optional since it allows you to have a full 1.33s gate after casting any ability.

Arcanes
Very flexible:
Arcane Hot Shot - free 300% crit chance that is easy to upkeep with neutron star. Use this for crit based weapons, and dont use this for laetum/phemmor/felarx etc.
Molt Efficiency - extra duration
Arcane aegis - optional for passive shield regen/lazy gating
Energize is optional for energy sustain.

Helminth

Subsume over either 2 or 3, depending on if you prefer to be mobile with Wormhole or not.

Nourish - Gives energy multiplier, viral dmg boost to weapons and also adds viral damage/status to Null Star particles allowing 1 to passively prime viral in a huge AOE. Can adjust efficiency if you prefer to run at 45%. For a meme Neutron star DPS build with Nourish see : https://overframe.gg/build/442240/

Silence - Prevents eximus and acolyte abilities, stuns enemies briefly which is prolonged by slow from Molecular Prime

Pillage - Strips armor and returns shields for shield gating

Archon Shards
ONE to TWO Amber Cast Speed - greatly improves the feel of casting Molecular Prime
TWO Tauforged Violet Equilibrium shards - optional but allows you to drop Equilibrium
ONE Crimson Tauforged Strength - gives strength to hit 150% strength threshold, allowing you to drop Power Drift for Primed Sure Footed or Escape Velocity
Flexible Crimson Tauforged Duration - adds more duration for molecular prime spread

ARSENAL

Any good crit based weapon can benefit from arcane hotshot, including most of the incarnons.

Here is a small list of my favourite incarnon crit weapons:
Primary: [Torid] Incarnon, [Boar] Incarnon, [Strun] Incarnon, [Sybaris] Incarnon, [Burston] Incarnon
Secondary: [Dual Toxocyst] Incarnon, [Furis] Incarnon, [Synoid Gammacor] Incarnon, [Prisma Angstrum] Incarnon, [Sicarus Prime] Incarnon
Melee: [Nami Solo] Incarnon, Okina prime Incarnon, Furax Wraith Incarnon, Innodem, Dual Ichor Incarnon

Here is a small list of my favourite non-incarnon crit weapons in no particular order:
Primary: AX-52, EFV5-Jupiter, [Reconifex], [Tenet Glaxion], [Coda Bassocyst], [Coda Synapse], [Coda Sporothrix], [Vadarya Prime]
Secondary: Coda Dual Torxica, [Coda Catabolyst], [Knell Prime]
Melee: Prisma Ohma, Dual Viciss, Tenet Agendus, Tak & Lug

SPECIAL INTERACTIONS
Molecular Prime's explosions can inherit many "on-kill" special effects such as:

Devouring Attrition
The 2000% multiplier on 50% of non-crits from first generation Incarnon Weapons means if you kill enemies affected by molecular prime using a [Phenmor], 50% of the resulting on death molecular prime explosions will deal 800 x 21 damage = 16,800 damage in 10 to 20m range. Adding strength, vulnerability and viral status we can multiply this to over 200k damage in AOE with a small chance to proc a corresponding blast status.

• Phenmor: https://overframe.gg/build/314745
• Laetim: https://overframe.gg/build/315005/
• Felarx: https://overframe.gg/build/328134/felarx/the-devastating-void-extreme-raw-damage-cold-corrosive-one-shot/

[Acid Shells]
Mods like [Acid Shells] for [Sobek], [Thermagnetic Shells] for [Detron] and [Vulcan Blitz] of [Jat Kittag] can trigger if an enemy is killed by the molecular prime explosion, as long as you get an initial kill with the weapon. When buffed with molecular prime and viral status from nourish or xatas whisper, this can create a chain reaction to nuke rooms, but is dependent on enemy density.

• Sobek: https://overframe.gg/build/892008/
• Jat Kittag: https://overframe.gg/build/692369/

Amalgam [Argonak]
Enemies kill by a dagger while amalgam [Argonak] is equipped will cause the resulting explosion to also trigger argonak strip in an AOE.
Argonak build (for both DPS to stack Gun and blade on Ceramic Dagger and as passive statstick): https://overframe.gg/build/891981/
Ceramic Dagger: https://overframe.gg/build/468904/
Innodem: https://overframe.gg/build/328180/

Okina Incarnon Spectral Daggers
Primed enemies killed by a spectral dagger can release an explosion that can re-trigger [Okina] spectral daggers if the explosion kills, creating a feedback loop provided the enemies are weak enough to actually die to both spectral daggers and molecular prime explosions
https://overframe.gg/build/668223/

Dual Ichor
Dual Ichors passive is activated from explosions.
https://overframe.gg/build/572811/

ANTIMATTER DROP
Each antimatter drop orb can absorb a maximum damage of 25,000 (not affected by crits or status) and output a maximum of 200K damage as radiation damage. Weapons that can easily hit 25,000 raw damage in one shot include Boar, Felarx, Opticor, Exergis, Tenet Arca Plasmor and Tigris Prime/[Sancti Tigris].