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Revision Log:
v 1.X.X >> Build identity changes / Complete build overhaul
v X.1.X >> Central idea stays; only mod order changes / or Major guide rework
v X.X.1 >> No change in setup; Minor guide edits only
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Why do we use?
This Mire is a 5x heavy slam setup designed around its forced ragdoll / toxin on heavy slams / Afflictions. This means we get at least 6x forced / enhanced and triple dipped toxin procs every slam
Progenitors are preference and flexible depending on playstyle;
MAGNETIC PROGEN -- Optional for ripping through overguard, the only thing toxin is weak against.
COLD PROGEN -- Combines to make raw viral. [Mire] has forced toxin on heavy slams which is based on whatever total damage anyways, which makes raw viral viable
TOXIN PROGEN -- Pure toxin max dots for Afflictions. This is probably the best progen for general use or if priming above mentions. *Remember; progenitors are physical damage, they can only indirectly affect damage of dots by increasing base damage / weight and chance to proc, they will provide no elemental bonuses.
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PFS -- Raw elemental damage with a toxin mod. Mire has FORCED toxin on heavy slams.
G Reflex -- For initial combo + combo efficiency for 5x slamming
Seismic Wave -- Multiplicative Slam Damage
2x SACRIFICIAL -- Necessary to reach 100% CC on heavy slams at 5x for guarenteed crits.
- Sac Pressure is multiplicative to Seismic
G Elementalist -- Status damage for status / forced Tox Afflictions. Also gives minor chance on kill.
Smite -- For double dipping dots and triple dipping Afflictions, must use if able.
AFFLICTIONS -- Status effects that are applied during an attack that ragdolls or flings enemies (BOTH Ragdoll AND Toxin are FORCED on all heavy slams on Mire), are applied x6.
Afflictions is a separate damage calculation, basically means faction / status damage bonuses are applied again
Afflictions uses the cumulative average damage of ALL status effects present per target when applying additional stacks.
From Wiki:

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What the Hell is 'Double Dipping'?
People often use 'dipping' out of context and wrong, so i will explain. Dipping refers to when a specific value or multiplier appears in multiple damage formulas during the final damage calculation.
When it IS double dipping -- One value is applied to multiple formulas, say (1x) Our Smite multiplier appears once in base damage formula, (2x) a second time in status DoT formula, and in some cases, (x3) Smite appears a third time in the formula for Melee Influence. Our Smite mod has been therefore 'triple dipped'.
When it is NOT dipping – One value is applied to a single formula multiple times, this is when a value is squared, not double dipped. For example, and to stay with the topic, some people like to say that electric is able to double dip from enemy part multipliers and triple dip from faction bonuses, but this is not how that works. When electric counts part multipliers a second time, it is doing so in the same damage formula, so electric is squaring the bonus, not double dipping it. So in such case we would say that electric is squaring (applying twice) a headshot bonus and double dipping a faction mod.